Vascular factors and their role in the development of obstetric and perinatal complications in women with hepatitis B virus

Purpose - to assess the role of vascular factors in development obstetric and perinatal complications women with hepatitis B virus (HBV). Materials methods. The serum parameters peripheral venous blood were studied 86 pregnant HBV (the main group, which was divided into 2 subgroups: HBV1 38 complications; HBV2 48 without significant gestational complications) 50 infectious liver disease control group). state platelet coagulation links haemostasis system indicators endothelial function (nitric oxide endothelin-1) determined. Results. In HBV, a relative decrease number platelets an increase their aggregation capacity von Willebrand factor concentration found, fibrinogen slight prothrombin index, recalcification time, international normalized ratio activated partial thromboplastin time. detected changes are even more pronounced (HBV1 subgroup): against background thrombocytopenia, anisocytosis ability platelets, level D-dimer significantly. Endothelial dysfunction found subgroup (a nitric endothelin-1). Conclusions. haemostatic can be characterized as unstable equilibrium, easily disturbed by various exo- endogenous factors, is observed manifested prothrombotic changes. Established leading link pathogenesis this category patients. research carried out accordance principles Helsinki Declaration. study protocol approved Local Ethics Committee participating institution. informed consent patient obtained for conducting studies. No conflict interests declared authors.